NSJ Bioreagents
SKU:RQ5238
Ch-TOG Antibody / CKAP5
Ch-TOG Antibody / CKAP5
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Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene. It is mapped to 11p11.2. This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human, Mouse, Rat |
| Application | WB, IHC-P, ICC/IF, Direct ELISA |
| Application Details | Western blot: 0.5-1ug/ml, Immunohistochemistry (FFPE): 1-2ug/ml, Immunocytochemistry/Immunofluorescence: 2-4ug/ml, Direct ELISA: 0.1-0.5ug/ml |
| Application Note | Optimal dilution of the Ch-TOG antibody should be determined by the researcher. |
| Localization | Cytoplasmic |
| Immunogen | Amino acids M1-L221 from the human protein were used as the immunogen for the Ch-TOG antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide |
| Purity | Affinity purified |
| Storage | Store the Ch-TOG antibody at -20oC. |
| Limitation | This Ch-TOG antibody is available for research use only. |
| Uniprot # | Q14008 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/ch-tog-antibody-ckap5-rq5238 |
| Title | Ch-TOG Antibody / CKAP5 |
| Description | Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene. It is mapped to 11p11.2. This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. |
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