NSJ Bioreagents
SKU:RQ8767
CENP-R Antibody / Centromere protein R / ITGB3BP
CENP-R Antibody / Centromere protein R / ITGB3BP
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Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene. This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human |
| Application | WB, IF, ELISA |
| Application Details | Western blot: 1-2ug/ml,Immunofluorescence: 5ug/ml,ELISA: 0.1-0.5ug/ml |
| Application Note | Optimal dilution of the CENP-R antibody should be determined by the researcher. |
| Localization | Nuclear, cytoplasmic |
| Immunogen | An E.coli-derived human recombinant protein (amino acids M1-N177) was used as the immunogen for the CENP-R antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| Purity | Antigen affinity chromatography |
| Storage | After reconstitution, the CENP-R antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This CENP-R antibody is available for research use only. |
| Uniprot # | Q13352 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/cenp-r-antibody-centromere-protein-r-itgb3bp-rq8767 |
| Title | CENP-R Antibody / Centromere protein R / ITGB3BP |
| Description | Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene. This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. |
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