NSJ Bioreagents
SKU:R30120
CEACAM5 Antibody / CEA
CEACAM5 Antibody / CEA
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CEA (Carcinoembryonic antigen), also called CEACAM5, is a glycoprotein involved in cell adhesion. It is normally produced during fetal development, but the production of CEACAM5 stops before birth. Therefore, it is not usually present in the blood of healthy adults, although levels are raised in heavy smokers. CEACAM5 is a glycosyl phosphatidyl inositol(GPI)-cell surface anchored glycoprotein whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells. CEACAM5 and related genes make up the CEA family belonging to the immunoglobulin superfamily. In humans, the carcinoembryonic antigen family consists of 29 genes, 18 of which are normally expressed.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human |
| Application | WB, IHC-P, ELISA (protein) |
| Application Details | Western blot: 0.5-1ug/ml,IHC (FFPE): 0.5-1ug/ml,ELISA: 0.1-0.5ug/ml (human protein tested) |
| Application Note | The stated application concentrations are suggested starting amounts. Titration of the CEACAM5 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | Full length mouse recombinant protein was used as the immunogen for this CEACAM5 antibody. |
| Buffer | Lyophilized from 1X PBS with 0.025% sodium azide |
| Purity | Antigen affinity |
| Storage | After reconstitution, the CEACAM5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This CEACAM5 antibody is available for research use only. |
| Uniprot # | P06731 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/ceacam5-antibody-cea-r30120 |
| Title | CEACAM5 Antibody / CEA |
| Description | CEA (Carcinoembryonic antigen), also called CEACAM5, is a glycoprotein involved in cell adhesion. It is normally produced during fetal development, but the production of CEACAM5 stops before birth. Therefore, it is not usually present in the blood of healthy adults, although levels are raised in heavy smokers. CEACAM5 is a glycosyl phosphatidyl inositol(GPI)-cell surface anchored glycoprotein whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells. CEACAM5 and related genes make up the CEA family belonging to the immunoglobulin superfamily. In humans, the carcinoembryonic antigen family consists of 29 genes, 18 of which are normally expressed. |
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