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NSJ Bioreagents
SKU:F55034-0.08ML
CDKN2D Antibody / p19-INK4d
CDKN2D Antibody / p19-INK4d
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$205.00 USD
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p19 / Cyclin-dependent kinase 4 inhibitor D is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human, Mouse |
| Application | FACS, IHC-P, WB |
| Application Details | Flow cytometry: 1:10-1:50 (1x10e6 cells), Immunohistochemistry (FFPE): 1:10-1:50, Western blot: 1:500-1:1000 |
| Application Note | The stated application concentrations are suggested starting points. Titration of the CDKN2D antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Localization | Cytoplasmic, nuclear |
| Immunogen | A portion of amino acids 15-43 from the human protein was used as the immunogen for the CDKN2D antibody. |
| Purity | Antigen affinity purified |
| Storage | Aliquot the CDKN2D antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This CDKN2D antibody is available for research use only. |
| Uniprot # | P55273 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/cdkn2d-antibody-p19-ink4d-f55034 |
| Title | CDKN2D Antibody / p19-INK4d |
| Description | p19 / Cyclin-dependent kinase 4 inhibitor D is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. |
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