NSJ Bioreagents
SKU:R30623
Cdk2 Antibody / Cell division protein kinase 2
Cdk2 Antibody / Cell division protein kinase 2
Couldn't load pickup availability
Cyclin-Dependent Kinase 2 is also know as p33. The protein is highly homologous to p34 (CDC2) kinase and more significantly homologous to Xenopus Eg1 kinase, suggesting that<a href=../search_result.php?search_txt=cdk2>Cdk2</a>is the human homolog of Eg1. The gene is mapped to 12q13, the same region to which the<a href=../search_result.php?search_txt=cdk4>Cdk4</a>gene maps. Human Cyclin A binds independently to two kinases, p34/Cdc2) or p33/Cdk2. In adenovirus-transformed cells, the viral E1A oncoprotein seems to associate with p33/Cyclin A but not with p34(cdc2)/cyclin A. The gene for p33 shares 65% sequence identity with p34(cdc2). Cdk2 plays a unique role in cell cycle regulation of vertebrate cells.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human, Mouse, Rat |
| Application | WB |
| Application Details | Western blot: 0.5-1ug/ml |
| Application Note | The stated application concentrations are suggested starting amounts. Titration of the Cdk2 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | Amino acids 277-298 (AKAALAHPFFQDVTKPVPHLRL) were used as the immunogen for this Cdk2 antibody (100% homologous in human, mouse and rat). |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| Purity | Antigen affinity |
| Storage | After reconstitution, the Cdk2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This Cdk2 antibody is available for research use only. |
| Uniprot # | P24941 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/cdk2-antibody-cell-division-protein-kinase-2-r30623 |
| Title | Cdk2 Antibody / Cell division protein kinase 2 |
| Description | Cyclin-Dependent Kinase 2 is also know as p33. The protein is highly homologous to p34 (CDC2) kinase and more significantly homologous to Xenopus Eg1 kinase, suggesting that<a href=../search_result.php?search_txt=cdk2>Cdk2</a>is the human homolog of Eg1. The gene is mapped to 12q13, the same region to which the<a href=../search_result.php?search_txt=cdk4>Cdk4</a>gene maps. Human Cyclin A binds independently to two kinases, p34/Cdc2) or p33/Cdk2. In adenovirus-transformed cells, the viral E1A oncoprotein seems to associate with p33/Cyclin A but not with p34(cdc2)/cyclin A. The gene for p33 shares 65% sequence identity with p34(cdc2). Cdk2 plays a unique role in cell cycle regulation of vertebrate cells. |
Share
