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NSJ Bioreagents
SKU:RQ6966
Cdc2 related protein kinase 2 Antibody / CDK2
Cdc2 related protein kinase 2 Antibody / CDK2
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CDK2, Cyclin-Dependent Kinase 2, is also known as P33. The CDK2 protein was highly homologous to p34 (CDC2) kinase and more significantly homologous to Xenopus Eg1 kinase, suggesting that CDK2 is the human homolog of Eg1. The CDK2 gene is mapped to 12q13, the same region to which the CDK4 gene maps. Human cyclin A binds independently to 2 kinases, p34 (cdc2) or p33. In adenovirus-transformed cells, the viral E1A oncoprotein seems to associate with p33/cyclin A but not with p34 (cdc2)/cyclin A. The gene for p33 shares 65% sequence identity with p34 (cdc2). P33 (cdk2) plays a unique role in cell cycle regulation of vertebrate cells.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Clone | 6D5B5 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b |
| Species Reactivity | Human, Mouse, Rat |
| Application | WB, IHC-P |
| Application Details | Western blot: 0.5-1 ug/ml,Immunohistochemistry (FFPE): 2-5ug/ml |
| Application Note | Optimal dilution of the Cdc2 related protein kinase 2 antibody should be determined by the researcher. |
| Localization | Cytoplasmic, nuclear |
| Immunogen | Recombinant human protein (amino acids E81-L298) was used as the immunogen for the Cdc2 related protein kinase 2 antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| Purity | Antigen affinity purified |
| Storage | After reconstitution, the Cdc2 related protein kinase 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This Cdc2 related protein kinase 2 antibody is available for research use only. |
| Uniprot # | P24941 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/cdc2-related-protein-kinase-2-antibody-cdk2-6d5b5-rq6966 |
| Title | Cdc2 related protein kinase 2 Antibody / CDK2 |
| Description | CDK2, Cyclin-Dependent Kinase 2, is also known as P33. The CDK2 protein was highly homologous to p34 (CDC2) kinase and more significantly homologous to Xenopus Eg1 kinase, suggesting that CDK2 is the human homolog of Eg1. The CDK2 gene is mapped to 12q13, the same region to which the CDK4 gene maps. Human cyclin A binds independently to 2 kinases, p34 (cdc2) or p33. In adenovirus-transformed cells, the viral E1A oncoprotein seems to associate with p33/cyclin A but not with p34 (cdc2)/cyclin A. The gene for p33 shares 65% sequence identity with p34 (cdc2). P33 (cdk2) plays a unique role in cell cycle regulation of vertebrate cells. |
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