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NSJ Bioreagents
SKU:RQ4104
Cd8 alpha Antibody
Cd8 alpha Antibody
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$449.00 USD
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The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. It is mapped to 2p11.2. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene also encodes the CD8 alpha chain isoforms.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Mouse, Rat |
| Application | WB, IHC-P, FACS, ELISA |
| Application Details | Western Blot: 0.5-1ug/ml,IHC (FFPE): 1-2ug/ml,FACS: 1-3ug/10^6 cells,Direct ELISA: 0.1-0.5ug/ml |
| Application Note | Optimal dilution of the Cd8 alpha antibody should be determined by the researcher. |
| Localization | Cytoplasmic, membrane, secreted |
| Immunogen | A recombinant mouse partial protein corresponding to amino acids K28-Y196 was used as the immunogen for the Cd8 alpha antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide |
| Purity | Antigen affinity purified |
| Storage | After reconstitution, the Cd8 alpha antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This Cd8 alpha antibody is available for research use only. |
| Uniprot # | P01731 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/cd8-alpha-antibody-rq4104 |
| Title | Cd8 alpha Antibody |
| Description | The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. It is mapped to 2p11.2. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene also encodes the CD8 alpha chain isoforms. |
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