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NSJ Bioreagents
SKU:F54091-0.05ML
CD59 Antibody (Center Region)
CD59 Antibody (Center Region)
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Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. [UniProt]
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Application | WB |
| Application Details | Western blot: 1:2000 |
| Application Note | The stated application concentrations are suggested starting points. Titration of the CD59 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of amino acids 74-110 from human CD59 was used as the immunogen for the CD59 antibody. |
| Purity | Antigen affinity |
| Storage | Aliquot the CD59 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This CD59 antibody is available for research use only. |
| Uniprot # | P13987 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/cd59-antibody-center-region-f54091 |
| Title | CD59 Antibody (Center Region) |
| Description | Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. [UniProt] |
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