Cd163 Antibody

Cd163 is a type I transmembrane glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily. It is highly expressed on cells of the monocyte/macrophage lineage, where it functions as a hemoglobin-haptoglobin complex receptor. By mediating clearance of hemoglobin from sites of tissue damage or intravascular hemolysis, Cd163 plays a central role in protecting tissues from oxidative stress and inflammation. A Cd163 antibody is frequently used to study macrophage biology, immune regulation, and tissue remodeling in both mouse and rat models. <br><br> Cd163 expression is strongly associated with alternatively activated (M2) macrophages, which are involved in anti-inflammatory processes, tissue repair, and immunosuppression. This makes Cd163 a valuable marker for identifying macrophage polarization states. Employing a Cd163 antibody allows researchers to investigate the dynamics of macrophage activation in response to injury, infection, or disease progression. <br><br> Beyond its role in hemoglobin clearance, Cd163 has broader immunomodulatory functions. Engagement of Cd163 can trigger anti-inflammatory signaling cascades and promote the release of heme oxygenase-1, further contributing to cytoprotection. Dysregulated Cd163 expression has been implicated in conditions such as sepsis, atherosclerosis, and chronic inflammatory diseases. In cancer, Cd163-positive macrophages are often linked to tumor-associated macrophages (TAMs), which can support tumor growth and immune evasion. A Cd163 antibody is therefore a powerful tool in both basic immunology and translational research. <br><br> NSJ Bioreagents provides a high-quality Cd163 antibody validated for use in western blot, immunohistochemistry, and flow cytometry. Choosing a Cd163 antibody from NSJ Bioreagents ensures reliable performance and reproducibility in studies of macrophage biology, immune responses, and inflammation in rodent models.

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