NSJ Bioreagents
SKU:RQ6361
CBX5 Antibody / HP1A / HP1 alpha
CBX5 Antibody / HP1A / HP1 alpha
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This gene encodes the highly conserved nonhistone protein Chromobox protein homolog 5, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Purified |
| Clone | 8G6 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b |
| Species Reactivity | Human, Mouse, Rat |
| Application | WB, IHC-P, IF, FACS |
| Application Details | Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 2-5ug/ml,Immunofluorescence (FFPE): 5ug/ml,Flow cytometry: 1-3ug/million cells |
| Application Note | Optimal dilution of the CBX5 antibody should be determined by the researcher. |
| Localization | Nuclear |
| Immunogen | Recombinant human protein (amino acids M1-S191) was used as the immunogen for the CBX5 antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| Purity | Antigen affinity purified |
| Storage | After reconstitution, the CBX5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This CBX5 antibody is available for research use only. |
| Uniprot # | P45973 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/cbx5-antibody-hp1a-hp1-alpha-8g6-rq6361 |
| Title | CBX5 Antibody / HP1A / HP1 alpha |
| Description | This gene encodes the highly conserved nonhistone protein Chromobox protein homolog 5, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
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