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NSJ Bioreagents
SKU:F54853-0.08ML
Caveolin-3 Antibody / CAV3
Caveolin-3 Antibody / CAV3
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CAV3 is a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in its gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD).
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Application | WB, IHC-P, FACS |
| Application Details | Western blot: 1:500-1:1000, Immunohistochemistry (FFPE): 1:10-1:50, Flow cytometry: 1:10-1:50 (1x10e6 cells) |
| Application Note | The stated application concentrations are suggested starting points. Titration of the Caveolin-3 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Localization | Cytoplasmic |
| Immunogen | A portion of amino acids 5-31 from the human protein was used as the immunogen for the Caveolin-3 antibody. |
| Purity | Purified |
| Storage | Aliquot the Caveolin-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This Caveolin-3 antibody is available for research use only. |
| Uniprot # | P56539 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/caveolin-3-antibody-cav3-f54853 |
| Title | Caveolin-3 Antibody / CAV3 |
| Description | CAV3 is a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in its gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). |
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