• Western blot testing of human 1) HeLa, 2) A549, 3) 22RV1, 4) HepG2 and 5) Caco-2 lysate with CASR antibody at 0.5ug/ml. Predicted molecular weight ~121 kDa, but is routinely observed at up to ~160 kDa.
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NSJ Bioreagents

RQ4484

CASR Antibody / Calcium Sensing Receptor

CASR Antibody / Calcium Sensing Receptor

$449.00 USD
$449.00 USD
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The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

Specifications

Family Primary antibody
Formulation 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format Purified
Clone 11E9.
Host Animal Mouse
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b
Species Reactivity Human
Application WB
Application Details Western blot: 0.5-1ug/ml
Application Note Optimal dilution of the CASR antibody should be determined by the researcher.
Localization Cell membrane
Immunogen Human CASR recombinant protein (amino acids Q926-S1078) was used as the immunogen for the CASR antibody.
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Purity Protein G affinity
Storage After reconstitution, the CASR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitation This CASR antibody is available for research use only.
Uniprot # P41180
Status Available
PDF Link https://www.nsjbio.com/tds-pdf/casr-antibody-calcium-sensing-receptor-11e9-rq4484
Title CASR Antibody / Calcium Sensing Receptor
Description The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.
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