NSJ Bioreagents
SKU:F55132-0.08ML
CAPN3 Antibody / Calpain 3
CAPN3 Antibody / Calpain 3
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Calpain 3 is a member of the calpain family of proteases, which are enzymes that break down proteins in the body. Unlike other calpain enzymes that are present in various tissues, Calpain 3 is predominantly found in skeletal muscle. Its main function is to regulate the turnover of muscle proteins, ensuring that they are properly maintained and repaired. One of the key roles of Calpain 3 is to maintain the structural integrity of muscle fibers. It is involved in the breakdown of damaged or misfolded proteins, preventing them from accumulating and causing muscle dysfunction. Additionally, Calpain 3 plays a vital role in muscle regeneration, helping to repair damaged fibers and promote muscle growth. Deficiencies in Calpain 3 have been linked to various muscle disorders, including limb-girdle muscular dystrophy type 2A. In individuals with this condition, mutations in the CAPN3 gene lead to impaired muscle function and weakness.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Application | WB, IHC-P, FACS |
| Application Details | Western blot: 1:500-1:1000,Immunohistochemistry (FFPE): 1:50-1:100,Flow cytometry: 1:10-1:50 per million cells in 0.1ml |
| Application Note | The stated application concentrations are suggested starting amounts. Titration of the CAPN3 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of amino acids 603-632 from the human protein was used as the immunogen for this CAPN3 antibody. |
| Storage | Store at 4oC for up to one month. For long term, aliquot the CAPN3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This CAPN3 antibody is available for research use only. |
| Uniprot # | P20807 |
| Status | Available |
| PDF Link | http://www.nsjbio.com/tds-pdf/capn3-antibody-calpain-3-f55132 |
| Title | CAPN3 Antibody / Calpain 3 |
| Description | Calpain 3 is a member of the calpain family of proteases, which are enzymes that break down proteins in the body. Unlike other calpain enzymes that are present in various tissues, Calpain 3 is predominantly found in skeletal muscle. Its main function is to regulate the turnover of muscle proteins, ensuring that they are properly maintained and repaired. One of the key roles of Calpain 3 is to maintain the structural integrity of muscle fibers. It is involved in the breakdown of damaged or misfolded proteins, preventing them from accumulating and causing muscle dysfunction. Additionally, Calpain 3 plays a vital role in muscle regeneration, helping to repair damaged fibers and promote muscle growth. Deficiencies in Calpain 3 have been linked to various muscle disorders, including limb-girdle muscular dystrophy type 2A. In individuals with this condition, mutations in the CAPN3 gene lead to impaired muscle function and weakness. |
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