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NSJ Bioreagents
SKU:F54096-0.05ML
Calnexin Antibody (C-Terminal Region)
Calnexin Antibody (C-Terminal Region)
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Calnexin is a calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse. [UniProt]
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human, Mouse, Rat |
| Application | WB |
| Application Details | Western blot: 1:2000 |
| Application Note | The stated application concentrations are suggested starting points. Titration of the Calnexin antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of amino acids 560-592 from human Calnexin was used as the immunogen for the Calnexin antibody. |
| Purity | Antigen affinity |
| Storage | Aliquot the Calnexin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This Calnexin antibody is available for research use only. |
| Uniprot # | P27824 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/calnexin-antibody-c-terminal-region-f54096 |
| Title | Calnexin Antibody (C-Terminal Region) |
| Description | Calnexin is a calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse. [UniProt] |
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