NSJ Bioreagents
SKU:R36502-100UG
Cadherin 5 Antibody / VE Cadherin
Cadherin 5 Antibody / VE Cadherin
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Cadherin 5 is primarily expressed in endothelial cells, where it plays a critical role in regulating cell-cell adhesion and maintaining the integrity of the vascular barrier. Through its interactions with other Cadherin molecules and cytoskeletal components, Cadherin 5 helps to form adherens junctions, specialized structures that hold adjacent cells together and facilitate cell communication. Research has shown that mutations or dysregulation of Cadherin 5 can lead to various pathologies, including vascular dysfunction, increased permeability of blood vessels, and impaired wound healing. In addition, Cadherin 5 has been implicated in the progression of cancer, as aberrant expression of this molecule can promote tumor invasion and metastasis.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide |
| Format | Antigen affinity purified |
| Host Animal | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Species Reactivity | Human |
| Application | IF, FACS, ELISA (peptide) |
| Application Details | Immunofluorescence: 10ug/ml,Flow cytometry: 1ug/million cell in 0.1ml,ELISA (peptide) LOD: 1:128000 |
| Application Note | Optimal dilution of the Cadherin 5 antibody should be determined by the researcher. |
| Localization | Cytoplasm, cell membrane, cell junctions |
| Immunogen | Amino acids KQARAHGKSVPE were used as the immunogen for this Cadherin 5 antibody. |
| Purity | Antigen affinity |
| Storage | Aliquot and store the Cadherin 5 antibody at -20oC. |
| Limitation | This Cadherin 5 antibody is available for research use only. |
| Uniprot # | P33151 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/cadherin-5-antibody-ve-cadherin-r36502 |
| Title | Cadherin 5 Antibody / VE Cadherin |
| Description | Cadherin 5 is primarily expressed in endothelial cells, where it plays a critical role in regulating cell-cell adhesion and maintaining the integrity of the vascular barrier. Through its interactions with other Cadherin molecules and cytoskeletal components, Cadherin 5 helps to form adherens junctions, specialized structures that hold adjacent cells together and facilitate cell communication. Research has shown that mutations or dysregulation of Cadherin 5 can lead to various pathologies, including vascular dysfunction, increased permeability of blood vessels, and impaired wound healing. In addition, Cadherin 5 has been implicated in the progression of cancer, as aberrant expression of this molecule can promote tumor invasion and metastasis. |
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