NSJ Bioreagents
SKU:F54374-0.08ML
Cadherin 4 Antibody / CDH4 / R-Cadherin
Cadherin 4 Antibody / CDH4 / R-Cadherin
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CDH4 is a classical cadherin from the cadherin superfamily. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Application | IHC-P, IF, FACS, WB |
| Application Details | Immunohistochemistry (FFPE): 1:25,Immunofluorescence: 1:25,Flow cytometry: 1:25 (1x10e6 cells),Western blot: 1:500-1:2000 |
| Application Note | The stated application concentrations are suggested starting points. Titration of the Cadherin 4 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of amino acids 175-203 from the human protein was used as the immunogen for the Cadherin 4 antibody. |
| Purity | Antigen affinity purified |
| Storage | Aliquot the Cadherin 4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This Cadherin 4 antibody is available for research use only. |
| Uniprot # | P55283 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/cadherin-4-antibody-cdh4-r-cadherin-f54374 |
| Title | Cadherin 4 Antibody / CDH4 / R-Cadherin |
| Description | CDH4 is a classical cadherin from the cadherin superfamily. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. |
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