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NSJ Bioreagents
SKU:F51211-0.08ML
C5 Antibody
C5 Antibody
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$205.00 USD
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C5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Application | IHC, FACS, WB, ELISA |
| Application Details | Western blot: 1:1000,Immunohistochemistry (Paraffin): 1:50-1:100,Flow cytometry: 1:10-1:50 |
| Application Note | Titration of the C5 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of amino acids 253-281 from the human protein was used as the immunogen for this C5 antibody. |
| Purity | Antigen affinity |
| Storage | Aliquot the C5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This C5 antibody is available for research use only. |
| Uniprot # | P01031 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/c5-antibody-f51211 |
| Title | C5 Antibody |
| Description | C5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. |
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