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NSJ Bioreagents
SKU:RQ5301
C4A Antibody / Complement C4A
C4A Antibody / Complement C4A
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This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. [RefSeq]
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA |
| Format | Purified |
| Clone | AFHB-3 |
| Host Animal | Rabbit |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Species Reactivity | Human |
| Application | WB |
| Application Details | Western blot: 1:500-1:2000 |
| Application Note | Optimal dilution of the C4A antibody should be determined by the researcher. |
| Immunogen | A synthetic peptide specific to human C4A / Complement C4A was used as the immunogen for the C4A antibody. |
| Purity | Affinity purified |
| Storage | Store the C4A antibody at -20oC. |
| Limitation | This C4A antibody is available for research use only. |
| Uniprot # | P0C0L4 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/c4a-antibody-complement-c4a-afhb-3-rq5301 |
| Title | C4A Antibody / Complement C4A |
| Description | This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. [RefSeq] |
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