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NSJ Bioreagents
SKU:RQ5672
BUB1B Antibody / BubR1
BUB1B Antibody / BubR1
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Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene. This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Clone | 5I7 |
| Host Animal | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Species Reactivity | Human |
| Application | WB, IHC-P, IF, FACS |
| Application Details | Western blot: 0.5-1ug/ml,Immunohistochemistry: 1-2ug/ml,Immunofluorescence: 2-4ug/ml,Flow cytometry: 1-3ug/million cells |
| Application Note | Optimal dilution of the BUB1B antibody should be determined by the researcher. |
| Immunogen | Recombinant human protein (amino acids K26-E448) was used as the immunogen for the BUB1B antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide |
| Purity | Affinity purified |
| Storage | After reconstitution, the BUB1B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This BUB1B antibody is available for research use only. |
| Uniprot # | O60566 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/bub1b-antibody-bubr1-5i7-rq5672 |
| Title | BUB1B Antibody / BubR1 |
| Description | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene. This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. |
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