NSJ Bioreagents
SKU:F54968-0.08ML
Brain-specific angiogenesis inhibitor 1 Antibody / BAI1
Brain-specific angiogenesis inhibitor 1 Antibody / BAI1
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Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human, Mouse |
| Application | FACS, IHC-P, WB |
| Application Details | Flow cytometry: 1:10-1:50 (1x10e6 cells), Immunohistochemistry (FFPE): 1:10-1:50, Western blot: 1:500-1:1000 |
| Application Note | The stated application concentrations are suggested starting points. Titration of the Brain-specific angiogenesis inhibitor 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of amino acids 1537-1567 from the human protein was used as the immunogen for the Brain-specific angiogenesis inhibitor 1 antibody. |
| Purity | Antigen affinity purified |
| Storage | Aliquot the Brain-specific angiogenesis inhibitor 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This Brain-specific angiogenesis inhibitor 1 antibody is available for research use only. |
| Uniprot # | O14514 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/brain-specific-angiogenesis-inhibitor-1-antibody-bai1-f54968 |
| Title | Brain-specific angiogenesis inhibitor 1 Antibody / BAI1 |
| Description | Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas. |
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