NSJ Bioreagents
SKU:R32634
BMAL1 Antibody / Brain and muscle ARNT-like 1
BMAL1 Antibody / Brain and muscle ARNT-like 1
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Aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL), also called Brain and muscle ARNT-like 1 (BMAL1), is protein that in humans is encoded by the ARNTL gene. The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human, Mouse, Rat |
| Application | WB, FACS |
| Application Details | Western blot: 0.5-1ug/ml,Flow cytometry: 1-3ug/million cells |
| Application Note | Optimal dilution of the BMAL1 antibody should be determined by the researcher. |
| Immunogen | Amino acids H58-D156 from the human protein were used as the immunogen for the BMAL1 antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| Purity | Antigen affinity |
| Storage | After reconstitution, the BMAL1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This BMAL1 antibody is available for research use only. |
| Uniprot # | O00327 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/bmal1-antibody-brain-and-muscle-arnt-like-1-r32634 |
| Title | BMAL1 Antibody / Brain and muscle ARNT-like 1 |
| Description | Aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL), also called Brain and muscle ARNT-like 1 (BMAL1), is protein that in humans is encoded by the ARNTL gene. The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. |
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