NSJ Bioreagents
SKU:F54014-0.1ML
Beta Arrestin 1 Antibody
Beta Arrestin 1 Antibody
Couldn't load pickup availability
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. [UniProt]
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In PBS with 50% glycerol and 0.03% ProClin 300 |
| Format | Purified |
| Clone | 6A1-D7-C9 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b |
| Species Reactivity | Human |
| Application | WB |
| Application Details | Western blot: 1:500 |
| Application Note | The stated application concentrations are suggested starting points. Titration of the Beta Arrestin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A human recombinant protein was used as the immunogen for this Beta Arrestin 1 antibody. |
| Purity | Protein G affinity |
| Storage | Store the Beta Arrestin 1 antibody at -20oC. |
| Limitation | This Beta Arrestin 1 antibody is available for research use only. |
| Uniprot # | P49407 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/beta-arrestin-1-antibody-6a1-d7-c9-f54014 |
| Title | Beta Arrestin 1 Antibody |
| Description | Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. [UniProt] |
Share
