NSJ Bioreagents
SKU:RQ8699
Best1 Antibody / Bestrophin 1
Best1 Antibody / Bestrophin 1
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Bestrophin-1 (Best1) is a protein that in humans is encoded by the BEST1 gene. This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Mouse, Rat |
| Application | WB, ELISA |
| Application Details | Western blot: 1-2ug/ml,ELISA: 0.1-0.5ug/ml |
| Application Note | Optimal dilution of the Best1 antibody should be determined by the researcher. |
| Immunogen | An E.coli-derived mouse recombinant protein (amino acids V9-E551) was used as the immunogen for the Best1 antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| Purity | Antigen affinity chromatography |
| Storage | After reconstitution, the Best1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This Best1 antibody is available for research use only. |
| Uniprot # | O88870 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/best1-antibody-bestrophin-1-rq8699 |
| Title | Best1 Antibody / Bestrophin 1 |
| Description | Bestrophin-1 (Best1) is a protein that in humans is encoded by the BEST1 gene. This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms. |
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