NSJ Bioreagents
SKU:RQ4739
BCL2L11 Antibody / BIM
BCL2L11 Antibody / BIM
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The protein encoded by the BCL2L11 gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [RefSeq]
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA |
| Format | Purified |
| Clone | CBE-2 |
| Host Animal | Rabbit |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Species Reactivity | Human |
| Application | IHC-P, WB, IF |
| Application Details | Western blot: 1:500-1:1000,Immunohistochemistry (FFPE): 1:50-1:100,Immunofluorescence: 1:50-1:100 |
| Application Note | Optimal dilution of the BCL2L11 antibody should be determined by the researcher. |
| Immunogen | A synthetic peptide specific to human Bim / BCL2L11 was used as the immunogen for the Bim antibody. |
| Purity | Affinity purified |
| Storage | Store the BCL2L11 antibody at -20oC. |
| Limitation | This BCL2L11 antibody is available for research use only. |
| Uniprot # | O43521 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/bcl2l11-antibody-bim-cbe-2-rq4739 |
| Title | BCL2L11 Antibody / BIM |
| Description | The protein encoded by the BCL2L11 gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [RefSeq] |
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