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NSJ Bioreagents
SKU:F40298-0.08ML
BCL-6 Antibody
BCL-6 Antibody
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The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Clone | 305CT16.3.3 |
| Host Animal | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, k |
| Species Reactivity | Human |
| Application | WB, ELISA |
| Application Details | Western blot: 1:100-1:250 |
| Application Note | Titration of the BCL-6 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of amino acids 676-704 from the human protein was used as the immunogen for this BCL-6 antibody. |
| Purity | Purified |
| Storage | Aliquot the BCL-6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This BCL-6 antibody is available for research use only. |
| Uniprot # | P41182 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/bcl-6-antibody-305ct1633-f40298 |
| Title | BCL-6 Antibody |
| Description | The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. |
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