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NSJ Bioreagents
SKU:F42652-0.08ML
Bak Antibody
Bak Antibody
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$205.00 USD
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BAK belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAK localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Application | IHC, WB, ELISA |
| Application Details | IHC (Paraffin): 1:50-1:100,Western blot: 1:1000 |
| Application Note | Titration of the Bak antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of amino acids 56-91 from the human protein was used as the immunogen for this Bak antibody. |
| Purity | Antigen affinity |
| Storage | Aliquot the Bak antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This Bak antibody is available for research use only. |
| Uniprot # | Q16611 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/bak-antibody-f42652 |
| Title | Bak Antibody |
| Description | BAK belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BAK localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. |
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