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NSJ Bioreagents
SKU:F49441-0.08ML
BACE2 Antibody
BACE2 Antibody
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$205.00 USD
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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by BACE2. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Application | WB, FACS, ELISA |
| Application Details | Western blot: 1:1000,Flow Cytometry: 1:10-1:50 |
| Application Note | Titration of the BACE2 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of amino acids 336-365 from the human protein was used as the immunogen for this BACE2 antibody. |
| Purity | Purified |
| Storage | Aliquot the BACE2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This BACE2 antibody is available for research use only. |
| Uniprot # | Q9Y5Z0 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/bace2-antibody-f49441 |
| Title | BACE2 Antibody |
| Description | Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by BACE2. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. |
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