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NSJ Bioreagents
SKU:RQ8042
B-cell lymphoma/leukemia 11B Antibody / BCL11B
B-cell lymphoma/leukemia 11B Antibody / BCL11B
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B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene. This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human, Rat |
| Application | WB, IHC-P, IF, FACS, Direct ELISA |
| Application Details | Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 2-5ug/ml,Immunofluorescence: 5ug/ml,Flow cytometry: 1-3ug/million cells,Direct ELISA: 0.1-0.5ug/ml |
| Application Note | Optimal dilution of the B-cell lymphoma/leukemia 11B antibody should be determined by the researcher. |
| Localization | Nuclear |
| Immunogen | E. coli-derived recombinant human protein (amino acids Q10-A628) was used as the immunogen for the B-cell lymphoma/leukemia 11B antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| Purity | Antigen affinity purified |
| Storage | After reconstitution, the B-cell lymphoma/leukemia 11B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This B-cell lymphoma/leukemia 11B antibody is available for research use only. |
| Uniprot # | Q9C0K0 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/b-cell-lymphomaleukemia-11b-antibody-bcl11b-rq8042 |
| Title | B-cell lymphoma/leukemia 11B Antibody / BCL11B |
| Description | B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene. This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
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