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NSJ Bioreagents
SKU:F53762-0.08ML
AURKC Antibody
AURKC Antibody
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$205.00 USD
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Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Application | WB, IHC, ELISA |
| Application Details | Western blot: 1:1000,IHC (Paraffin): 1:50-1:100 |
| Application Note | Titration of the AURKC antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of the C-terminal region of the human protein was used as immunogen for this AURKC antibody. |
| Purity | Purified |
| Storage | Aliquot the AURKC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This AURKC antibody is available for research use only. |
| Uniprot # | Q9UQB9 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/aurkc-antibody-f53762 |
| Title | AURKC Antibody |
| Description | Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase. |
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