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NSJ Bioreagents
SKU:RQ6756
ATR Antibody / Ataxia telangiectasia and Rad3-related protein / FRP1
ATR Antibody / Ataxia telangiectasia and Rad3-related protein / FRP1
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Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene. The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human |
| Application | IF, Direct ELISA |
| Application Details | Immunofluorescence: 5ug/ml,Direct ELISA: 0.1-0.5ug/ml |
| Application Note | Optimal dilution of the ATR antibody should be determined by the researcher. |
| Localization | Nuclear |
| Immunogen | Recombinant human protein (amino acids E24-D1324) was used as the immunogen for the ATR antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| Purity | Antigen affinity purified |
| Storage | After reconstitution, the ATR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This ATR antibody is available for research use only. |
| Uniprot # | Q13535 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/atr-antibody-ataxia-telangiectasia-and-rad3-related-protein-frp1-rq6756 |
| Title | ATR Antibody / Ataxia telangiectasia and Rad3-related protein / FRP1 |
| Description | Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene. The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. |
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