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NSJ Bioreagents
SKU:R32492
ATP Citrate Lyase Antibody / ACL
ATP Citrate Lyase Antibody / ACL
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$449.00 USD
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ATP citrate lyase, aslo known as ACLY, is an enzyme that in animals represents an important step in fatty acid biosynthesis. ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer of apparently identical subunits. The product, acetyl-CoA, in animals serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. It is activated by insulin. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. In plants, ATP citrate lyase generates the acetyl-CoA for cytosolically-synthesized metabolites.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human, Mouse, Rat |
| Application | WB, IHC-P, IF/ICC, FACS |
| Application Details | Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 2-4ug/ml,Immunofluorescence/Immunocytochemistry (FFPE): 5ug/ml,Flow cytometry: 1-3ug/10^6 cells |
| Application Note | Differences in protocols and secondary/substrate sensitivity may require the ATP Citrate Lyase antibody to be titrated for optimal performance. |
| Localization | Cytoplasmic, nuclear |
| Immunogen | Amino acids M1-I180 from the human protein were used as the immunogen for the ATP Citrate Lyase antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| Purity | Antigen affinity |
| Storage | After reconstitution, the ATP Citrate Lyase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This ATP Citrate Lyase antibody is available for research use only. |
| Uniprot # | P53396 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/atp-citrate-lyase-antibody-acl-r32492 |
| Title | ATP Citrate Lyase Antibody / ACL |
| Description | ATP citrate lyase, aslo known as ACLY, is an enzyme that in animals represents an important step in fatty acid biosynthesis. ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer of apparently identical subunits. The product, acetyl-CoA, in animals serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. It is activated by insulin. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. In plants, ATP citrate lyase generates the acetyl-CoA for cytosolically-synthesized metabolites. |
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