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NSJ Bioreagents
SKU:F49022-0.08ML
ATF6 beta Antibody
ATF6 beta Antibody
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$205.00 USD
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ATF6 beta is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human, Hamster, Mouse |
| Application | IHC, WB, ELISA |
| Application Details | IHC (Paraffin): 1:25,Western blot: 1:1000 |
| Application Note | Titration of the ATF6 beta antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of amino acids 560-589 from the human protein was used as the immunogen for this ATF6 beta antibody. |
| Purity | Antigen affinity |
| Storage | Aliquot the ATF6 beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This ATF6 beta antibody is available for research use only. |
| Uniprot # | Q99941 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/atf6-beta-antibody-f49022 |
| Title | ATF6 beta Antibody |
| Description | ATF6 beta is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. |
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