NSJ Bioreagents
SKU:F54630-0.08ML
ARRB1 Antibody / Beta Arrestin 1
ARRB1 Antibody / Beta Arrestin 1
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Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Application | FACS, IF, IHC-P, WB |
| Application Details | Flow cytometry: 1:25 (1x10e6 cells), Immunofluorescence: 1:25, Immunohistochemistry (FFPE): 1:25, Western blot: 1:500-1:2000 |
| Application Note | The stated application concentrations are suggested starting points. Titration of the ARRB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Localization | Cytoplasmic, nuclear |
| Immunogen | A portion of amino acids 336-363 from the human protein was used as the immunogen for the ARRB1 antibody. |
| Purity | Antigen affinity purified |
| Storage | Aliquot the ARRB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This ARRB1 antibody is available for research use only. |
| Uniprot # | P49407 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/arrb1-antibody-beta-arrestin-1-f54630 |
| Title | ARRB1 Antibody / Beta Arrestin 1 |
| Description | Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. |
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