• Western blot testing of 1) rat testis, 2) mouse testis, 3) mouse thymus and 4) mouse HEPA1-6 cell lysate with Ark-1 antibody. Predicted molecular weight ~45 kDa.
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NSJ Bioreagents

RQ7273

Ark-1 Antibody / Aurora-related kinase 1 / Aurka

Ark-1 Antibody / Aurora-related kinase 1 / Aurka

$449.00 USD
$449.00 USD
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AURKA (Aurora kinase A), also called ARK-1 (Aurora-related kinase 1), AurA, AIK, AURORA2, BTAK, PPP1R47, STK7, STK15, and STK6 is a mitotic centrosomal protein kinase. The main role of AURKA/ARK-1 in tumor development is in controlling chromosome segregation during mitosis. Aurora A / Aurora-related kinase 1 is a member of a family of mitotic serine/threonine kinases. The AURKA gene is overexpressed in many human cancers. Ectopic overexpression in mammalian cells induces centrosome amplification, chromosome instability, and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53.

Specifications

Family Primary antibody
Formulation 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format Antigen affinity purified
Host Animal Rabbit
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Species Reactivity Mouse, Rat
Application WB, Direct ELISA
Application Details Western blot: 0.5-1ug/ml, Direct ELISA: 0.1-0.5ug/ml
Application Note Optimal dilution of the Ark-1 antibody should be determined by the researcher.
Immunogen Recombinant mouse protein (amino acids M1-S395) was used as the immunogen for the Ark-1 antibody.
Buffer Lyophilized from 1X PBS with 2% Trehalose
Purity Antigen affinity purified
Storage After reconstitution, the Ark-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitation This Ark-1 antibody is available for research use only.
Uniprot # P97477
Status Available
PDF Link https://www.nsjbio.com/tds-pdf/ark-1-antibody-aurora-related-kinase-1-aurka-rq7273
Title Ark-1 Antibody / Aurora-related kinase 1 / Aurka
Description AURKA (Aurora kinase A), also called ARK-1 (Aurora-related kinase 1), AurA, AIK, AURORA2, BTAK, PPP1R47, STK7, STK15, and STK6 is a mitotic centrosomal protein kinase. The main role of AURKA/ARK-1 in tumor development is in controlling chromosome segregation during mitosis. Aurora A / Aurora-related kinase 1 is a member of a family of mitotic serine/threonine kinases. The AURKA gene is overexpressed in many human cancers. Ectopic overexpression in mammalian cells induces centrosome amplification, chromosome instability, and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53.
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