NSJ Bioreagents
SKU:F50536-0.08ML
ApoE Antibody (Apolipoprotein E)
ApoE Antibody (Apolipoprotein E)
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Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III),in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Predicted Species Reactivity | Primate, Rabbit |
| Application | IHC, WB, ELISA |
| Application Details | Western blot: 1:1000,IHC (Paraffin): 1:10-1:50 |
| Application Note | Titration of the ApoE antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Localization | Cytoplasmic, membranous |
| Immunogen | A portion of amino acids 263-292 from the human protein was used as the immunogen for this ApoE antibody. |
| Purity | Antigen affinity |
| Storage | Aliquot the ApoE antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This ApoE antibody is available for research use only. |
| Uniprot # | P02649 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/apoe-antibody-apolipoprotein-e-f50536 |
| Title | ApoE Antibody (Apolipoprotein E) |
| Description | Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III),in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. |
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