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NSJ Bioreagents
SKU:R31342
Antithrombin III Antibody
Antithrombin III Antibody
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Antithrombin III (AT3), is the most important inhibitor of thrombin and other coagulation proteinases. It is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human, Mouse, Rat |
| Application | WB |
| Application Details | Western blot: 0.5-1ug/ml |
| Application Note | The stated application concentrations are suggested starting amounts. Titration of the Antithrombin III antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | An amino acid sequence from the N-terminus of human AT3 (TFYQHLADSKNDNDN) was used as the immunogen for this Antithrombin III antibody. |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal |
| Purity | Antigen affinity |
| Storage | After reconstitution, the Antithrombin III antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This Antithrombin III antibody is available for research use only. |
| Uniprot # | P01008 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/antithrombin-iii-antibody-r31342 |
| Title | Antithrombin III Antibody |
| Description | Antithrombin III (AT3), is the most important inhibitor of thrombin and other coagulation proteinases. It is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. |
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