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NSJ Bioreagents
SKU:F40721-0.08ML
Anti-Histone H3 Antibody
Anti-Histone H3 Antibody
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein targeted by this antibody is a replication-independent member of the histone H3 family.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Predicted Species Reactivity | Mouse, Rat, Bovine, Pig, Chicken, Zebrafish, Xenopus, Drosophila, C. elegans |
| Application | WB, ELISA |
| Application Details | Western blot: 1:1000 |
| Application Note | Titration of the anti-Histone H3 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of amino acids 1-30 from the human protein was used as the immunogen for this anti-Histone H3 antibody. |
| Purity | Antigen affinity |
| Storage | Aliquot the anti-Histone H3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This anti-Histone H3 antibody is available for research use only. |
| Uniprot # | P84243 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/anti-histone-h3-antibody-f40721 |
| Title | Anti-Histone H3 Antibody |
| Description | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein targeted by this antibody is a replication-independent member of the histone H3 family. |
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