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NSJ Bioreagents
SKU:N1046-25UG
Als2Cr2 Antibody / STRADB / ILPIP
Als2Cr2 Antibody / STRADB / ILPIP
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$225.00 USD
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Als2Cr2, also called STE20-related kinase adapter protein beta (STRAD beta) and ILPIP, is a serine/threonine protein kinase encoded by the STRADB gene, discovered as an XIAP interacting protein. It is a mediator of the XIAP/TAK1 activation of the JNK1 pathway, an apoptosis inhibition mechanism independent of XIAP inhibition of caspases. Alone, it only moderately activates JNKs, but its interaction with XIAP/TAK1 induces a much stronger activation of JNK1, protecting against Caspase 1- or Fas-induced apoptosis.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human, Mouse, Rat |
| Application | WB |
| Application Details | Western blot: 5-10ug/ml |
| Application Note | Provided assay concentrations are suggestions only, Als2Cr2 antibody titration may be required for optimal results. This antibody will detect the 418 (ILPIP alpha) and 280 (ILPIP beta) amino acid isoforms. |
| Immunogen | A recombinant protein fragment from the interior region of human Als2Cr2 was used as the immunogen for this antibody. |
| Buffer | 1X PBS, pH 7.4 |
| Purity | Protein A affinity chromatography |
| Storage | Aliquot the Als2Cr2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This Als2Cr2 antibody is available for research use only. |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/als2cr2-antibody-stradb-ilpip-n1046 |
| Title | Als2Cr2 Antibody / STRADB / ILPIP |
| Description | Als2Cr2, also called STE20-related kinase adapter protein beta (STRAD beta) and ILPIP, is a serine/threonine protein kinase encoded by the STRADB gene, discovered as an XIAP interacting protein. It is a mediator of the XIAP/TAK1 activation of the JNK1 pathway, an apoptosis inhibition mechanism independent of XIAP inhibition of caspases. Alone, it only moderately activates JNKs, but its interaction with XIAP/TAK1 induces a much stronger activation of JNK1, protecting against Caspase 1- or Fas-induced apoptosis. |
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