NSJ Bioreagents
SKU:F55116-0.08ML
AGER Antibody / RAGE
AGER Antibody / RAGE
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AGER is a cell surface receptor that is specifically activated by AGEs, which are formed when sugars react non-enzymatically with proteins or lipids. These AGEs are known to accumulate in various tissues over time, contributing to the development of complications like diabetic nephropathy, retinopathy, and neuropathy. AGER acts as a receptor for these AGEs, signaling pathways that lead to inflammation, oxidative stress, and tissue damage. Understanding the role of AGER in diabetes-related complications has significant implications for the development of novel therapeutic strategies. By targeting AGER and its downstream signaling pathways, researchers hope to mitigate the harmful effects of AGE accumulation in diabetic patients. In fact, recent studies have shown that blocking AGER with specific inhibitors can reduce inflammation and oxidative stress in diabetic animal models, offering promise for future treatments. In addition to its role in diabetes, AGER has also been implicated in other age-related diseases, such as Alzheimer's and cardiovascular disease. By studying the mechanisms by which AGER mediates these diseases, researchers can gain valuable insights into the underlying pathophysiology and identify new targets for intervention.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human, Mouse |
| Application | WB, IHC-P, FACS |
| Application Details | Western blot: 1:500-1:1000,Immunohistochemistry (FFPE): 1:10-1:50,Flow cytometry: 1:10-1:50 per million cells in 0.1ml |
| Application Note | The stated application concentrations are suggested starting amounts. Titration of the AGER antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of amino acids 24-52 from the human protein was used as the immunogen for this AGER antibody. |
| Purity | Antigen affinity |
| Storage | Store at 4oC for up to one month. For long term, aliquot the AGER antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This AGER antibody is available for research use only. |
| Uniprot # | Q15109 |
| Status | Available |
| PDF Link | http://www.nsjbio.com/tds-pdf/ager-antibody-rage-f55116 |
| Title | AGER Antibody / RAGE |
| Description | AGER is a cell surface receptor that is specifically activated by AGEs, which are formed when sugars react non-enzymatically with proteins or lipids. These AGEs are known to accumulate in various tissues over time, contributing to the development of complications like diabetic nephropathy, retinopathy, and neuropathy. AGER acts as a receptor for these AGEs, signaling pathways that lead to inflammation, oxidative stress, and tissue damage. Understanding the role of AGER in diabetes-related complications has significant implications for the development of novel therapeutic strategies. By targeting AGER and its downstream signaling pathways, researchers hope to mitigate the harmful effects of AGE accumulation in diabetic patients. In fact, recent studies have shown that blocking AGER with specific inhibitors can reduce inflammation and oxidative stress in diabetic animal models, offering promise for future treatments. In addition to its role in diabetes, AGER has also been implicated in other age-related diseases, such as Alzheimer's and cardiovascular disease. By studying the mechanisms by which AGER mediates these diseases, researchers can gain valuable insights into the underlying pathophysiology and identify new targets for intervention. |
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