NSJ Bioreagents
SKU:F54581-0.08ML
Additional sex combs-like protein 1 Antibody / ASXL1
Additional sex combs-like protein 1 Antibody / ASXL1
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This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human, Mouse |
| Application | WB, IHC-P, FACS, IF |
| Application Details | Western blot: 1:500-1:2000, Immunohistochemistry (FFPE): 1:25, Flow cytometry: 1:25 (1x10e6 cells), Immunofluorescence: 1:25 |
| Application Note | The stated application concentrations are suggested starting points. Titration of the Additional sex combs-like protein 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Localization | Nuclear |
| Immunogen | A portion of amino acids 521-549 from the human protein was used as the immunogen for the Additional sex combs-like protein 1 antibody. |
| Purity | Antigen affinity purified |
| Storage | Aliquot the Additional sex combs-like protein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This Additional sex combs-like protein 1 antibody is available for research use only. |
| Uniprot # | Q8IXJ9 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/additional-sex-combs-like-protein-1-antibody-asxl1-f54581 |
| Title | Additional sex combs-like protein 1 Antibody / ASXL1 |
| Description | This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. |
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