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NSJ Bioreagents
SKU:F41148-0.08ML
ACN9 Antibody / SDHAF3
ACN9 Antibody / SDHAF3
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ACN9/SDHAF3 plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. [UniProt]
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human, Mouse |
| Application | WB, IHC, ELISA |
| Application Details | Western blot: 1:500-1000,IHC (Paraffin): 1:50-1:100 |
| Application Note | Titration of the ACN9 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Localization | Cytoplasmic |
| Immunogen | A portion of amino acids 13-42 from the human protein was used as the immunogen for this ACN9 antibody. |
| Purity | Antigen affinity |
| Storage | Aliquot the ACN9 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This ACN9 antibody is available for research use only. |
| Uniprot # | Q9NRP4 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/acn9-antibody-sdhaf3-f41148 |
| Title | ACN9 Antibody / SDHAF3 |
| Description | ACN9/SDHAF3 plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. [UniProt] |
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