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NSJ Bioreagents
SKU:F50698-0.08ML
ACK1 Antibody / Activated CDC42 kinase 1
ACK1 Antibody / Activated CDC42 kinase 1
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Activated CDC42 kinase 1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human, Mouse |
| Predicted Species Reactivity | Bovine |
| Application | WB, IHC, ELISA |
| Application Details | Western blot: 1:500-1000,IHC (Paraffin): 1:50-1:100 |
| Application Note | Titration of the ACK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Localization | Cytoplasmic |
| Immunogen | A portion of amino acids 934-964 from the human protein was used as the immunogen for this ACK1 antibody. |
| Purity | Purified |
| Storage | Aliquot the ACK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This ACK1 antibody is available for research use only. |
| Uniprot # | Q07912 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/ack1-antibody-activated-cdc42-kinase-1-f50698 |
| Title | ACK1 Antibody / Activated CDC42 kinase 1 |
| Description | Activated CDC42 kinase 1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. |
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