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NSJ Bioreagents
SKU:F54362-0.08ML
Acid Sphingomyelinase Antibody / SMPD1
Acid Sphingomyelinase Antibody / SMPD1
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The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq].
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human |
| Application | IHC-P, WB, FACS |
| Application Details | Immunohistochemistry (FFPE): 1:25,Western blot: 1:500-1:2000,Flow cytometry: 1:25 (1x10e6 cells) |
| Application Note | The stated application concentrations are suggested starting points. Titration of the Acid Sphingomyelinase antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of amino acids 391-419 from the human protein was used as the immunogen for the Acid Sphingomyelinase antibody. |
| Purity | Antigen affinity purified |
| Storage | Aliquot the Acid Sphingomyelinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This Acid Sphingomyelinase antibody is available for research use only. |
| Uniprot # | P17405 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/acid-sphingomyelinase-antibody-smpd1-f54362 |
| Title | Acid Sphingomyelinase Antibody / SMPD1 |
| Description | The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq]. |
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