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NSJ Bioreagents
SKU:R30303
AChR Antibody (nicotinic)
AChR Antibody (nicotinic)
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AChR alpha, also called CHRNA, is mapped on 2q24-q32. This gene encodes the alpha subunit of the muscle acetylcholine receptor, which is the main target of pathogenic autoantibodies in autoimmune myasthenia gravis. The protein-coding sequence of the human alpha subunit gene is divided into 9 exons that correspond to different structural and functional domains of the precursor molecule.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human, Mouse, Rat |
| Application | WB |
| Application Details | Western blot: 0.5-1ug/ml |
| Application Note | Titration of the AChR antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | Amino acids 22-36 (EHETRLVAKLFKDYS) from the alpha subunit were used as the immunogen for this nicotinic AChR antibody (100% homologous in human and rat). |
| Buffer | Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal |
| Purity | Antigen affinity |
| Storage | Store the lyophilized AChR antibody at 4oC. After reconstitution, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This AChR antibody is available for research use only. |
| Uniprot # | P02708 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/achr-antibody-nicotinic-r30303 |
| Title | AChR Antibody (nicotinic) |
| Description | AChR alpha, also called CHRNA, is mapped on 2q24-q32. This gene encodes the alpha subunit of the muscle acetylcholine receptor, which is the main target of pathogenic autoantibodies in autoimmune myasthenia gravis. The protein-coding sequence of the human alpha subunit gene is divided into 9 exons that correspond to different structural and functional domains of the precursor molecule. |
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