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NSJ Bioreagents
SKU:F51596-0.08ML
ACCN1 Antibody / ASIC2
ACCN1 Antibody / ASIC2
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Amiloride-sensitive cation channel neuronal 1 is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN1 may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Predicted Species Reactivity | Mouse, Rat |
| Application | WB, IHC, FACS, ELISA |
| Application Details | Western blot: 1:500-1000,IHC (Paraffin): 1:25-1:50,Flow Cytometry: 1:10-1:50 |
| Application Note | Titration of the ACCN1 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Localization | Cytoplasmic |
| Immunogen | A portion of amino acids 120-148 from the human protein was used as the immunogen for this ACCN1 antibody. |
| Purity | Antigen affinity |
| Storage | Aliquot the ACCN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This ACCN1 antibody is available for research use only. |
| Uniprot # | Q16515 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/accn1-antibody-asic2-f51596 |
| Title | ACCN1 Antibody / ASIC2 |
| Description | Amiloride-sensitive cation channel neuronal 1 is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN1 may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. |
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