NSJ Bioreagents
SKU:RQ8786
ACAT1 Antibody / Acetyl-CoA acetyltransferase
ACAT1 Antibody / Acetyl-CoA acetyltransferase
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The Acetyl-CoA acetyltransferase protein, also called ACAT1, is an enzyme that catalyzes the conversion of Acetyl-CoA to acetoacetyl-CoA. This reaction is a key step in the fatty acid beta-oxidation pathway, which is essential for the breakdown of fatty acids and the production of energy. Additionally, ACAT1 plays a critical role in ketogenesis, a process that occurs during times of fasting or low carbohydrate intake. The structure of the Acetyl-CoA acetyltransferase protein is highly conserved among different species, indicating its importance in cellular metabolism. This enzyme contains an active site where the catalytic reaction takes place, as well as binding sites for its substrate and cofactors. The precise mechanism by which Acetyl-CoA is converted to acetoacetyl-CoA by this enzyme involves a series of chemical reactions that involve the transfer of acetyl groups.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA |
| Format | Purified |
| Clone | 29A55 |
| Host Animal | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Species Reactivity | Human, Mouse, Rat |
| Application | WB, IP |
| Application Details | Western blot: 1:500-1:2000,Immunoprecipitation: 1:50 |
| Application Note | Optimal dilution of the ACAT1 antibody should be determined by the researcher. |
| Immunogen | A synthetic peptide specific to human Acetyl-CoA acetyltransferase protein was used as the immunogen for the ACAT1 Antibody. |
| Purity | Affinity chromatography |
| Storage | Store the ACAT1 antibody at -20oC. |
| Limitation | This ACAT1 antibody is available for research use only. |
| Uniprot # | P24752 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/acat1-antibody-acetyl-coa-acetyltransferase-rq8786 |
| Title | ACAT1 Antibody / Acetyl-CoA acetyltransferase |
| Description | The Acetyl-CoA acetyltransferase protein, also called ACAT1, is an enzyme that catalyzes the conversion of Acetyl-CoA to acetoacetyl-CoA. This reaction is a key step in the fatty acid beta-oxidation pathway, which is essential for the breakdown of fatty acids and the production of energy. Additionally, ACAT1 plays a critical role in ketogenesis, a process that occurs during times of fasting or low carbohydrate intake. The structure of the Acetyl-CoA acetyltransferase protein is highly conserved among different species, indicating its importance in cellular metabolism. This enzyme contains an active site where the catalytic reaction takes place, as well as binding sites for its substrate and cofactors. The precise mechanism by which Acetyl-CoA is converted to acetoacetyl-CoA by this enzyme involves a series of chemical reactions that involve the transfer of acetyl groups. |
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