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NSJ Bioreagents
SKU:RQ6595
AASS Antibody / LKR / SDH
AASS Antibody / LKR / SDH
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Alpha-aminoadipic semialdehyde synthase (AASS), also called Lysine ketoglutarate reductase (LKR) and Saccharopine dehydrogenase (SDH) is an enzyme encoded by the AASS gene in humans and is involved in their major lysine degradation pathway. This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human, Mouse, Rat |
| Application | WB, IHC-P, IF, FACS, Direct ELISA |
| Application Details | Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 2-5ug/ml,Immunofluorescence (FFPE): 5ug/ml,Flow cytometry: 1-3ug/million cells,Direct ELISA: 0.1-0.5ug/ml |
| Application Note | Optimal dilution of the AASS antibody should be determined by the researcher. |
| Localization | Cytoplasmic |
| Immunogen | Recombinant human protein (amino acids E37-N865) was used as the immunogen for the AASS antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| Purity | Antigen affinity purified |
| Storage | After reconstitution, the AASS antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This AASS antibody is available for research use only. |
| Uniprot # | Q9UDR5 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/aass-antibody-lkr-sdh-rq6595 |
| Title | AASS Antibody / LKR / SDH |
| Description | Alpha-aminoadipic semialdehyde synthase (AASS), also called Lysine ketoglutarate reductase (LKR) and Saccharopine dehydrogenase (SDH) is an enzyme encoded by the AASS gene in humans and is involved in their major lysine degradation pathway. This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia. |
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