NSJ Bioreagents
SKU:RQ5292
5-Lipoxygenase Antibody / ALOX5
5-Lipoxygenase Antibody / ALOX5
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The ALOX5 gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. [RefSeq]
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA |
| Format | Purified |
| Clone | AECE-1 |
| Host Animal | Rabbit |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Species Reactivity | Human |
| Application | WB |
| Application Details | Western blot: 1:500-1:2000 |
| Application Note | Optimal dilution of the 5-Lipoxygenase antibody should be determined by the researcher. |
| Immunogen | A synthetic peptide specific to human 5-Lipoxygenase / ALOX5 was used as the immunogen for the 5-Lipoxygenase antibody. |
| Purity | Affinity purified |
| Storage | Store the 5-Lipoxygenase antibody at -20oC. |
| Limitation | This 5-Lipoxygenase antibody is available for research use only. |
| Uniprot # | P09917 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/5-lipoxygenase-antibody-alox5-aece-1-rq5292 |
| Title | 5-Lipoxygenase Antibody / ALOX5 |
| Description | The ALOX5 gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. [RefSeq] |
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