NSJ Bioreagents
SKU:RQ7304
5-HT2C Receptor Antibody / HTR2C
5-HT2C Receptor Antibody / HTR2C
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This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human, Rat |
| Application | WB, Direct ELISA |
| Application Details | Western blot: 0.5-1ug/ml, Direct ELISA: 0.1-0.5ug/ml |
| Application Note | Optimal dilution of the 5-HT2C Receptor antibody should be determined by the researcher. |
| Immunogen | Recombinant human protein (amino acids N372-V458) was used as the immunogen for the 5-HT2C Receptor antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| Purity | Antigen affinity purified |
| Storage | After reconstitution, the 5-HT2C Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This 5-HT2C Receptor antibody is available for research use only. |
| Uniprot # | P28335 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/5-ht2c-receptor-antibody-htr2c-rq7304 |
| Title | 5-HT2C Receptor Antibody / HTR2C |
| Description | This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. |
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