NS Antibody

Size

100ul

Clone Number

Aliases

NS antibody; Non-structural protein 1 antibody; NS1 antibody; NS1A antibody

Immunogen Species

Influenza A virus

UniProt ID

Q0HD54

Immunogen

Recombinant Influenza A virus Non-structural protein 1 protein (1-237AA)

Raised in

Rabbit

Species Reactivity

Influenza A virus

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

NS

Research Areas

N/A